A Mathematical Model of Angiogenesis in Glioblastoma Multiforme

This paper gives an introduction to the mechanisms involved in the development of aggressive brain tumors, specifically glioblastomas multiforme. The paper then introduces a mathematical model that predicts tumor growth, vascular development (angiogenesis), and the growth factors that affect them both. When angiogenesis is promoted, the model demonstrates more aggressive tumor growth, suggesting that anti-angiogenic therapy may slow tumor growth and provide an effective form of treatment. ∗[email protected] †[email protected] ‡[email protected] §[email protected]